Dopamine and Glutamate in Psychiatric Disorders (PDF)


Werner SchmidtWerner Schmidt

An illuminating summary of our current understanding of the interactive role of dopamine and glutamate in psychiatric diseases and the therapeutic strategies and possibilities for future treatment. Among the new ideas presented are hypotheses on the role of dopamine and glutamate in aggression, the glutamate system in anxiety disorders, glutamate and neurodegeneration, and on the origin and progression of Parkinson’s disease. Additional chapters offer novel insights into a variety of psychiatric diseases, including ADHD, stress, aggression, addiction, schizophrenia, depression, social phobias, dementias, bulimia, and neurodegenerative diseases like Parkinson’s and Alzheimer’s diseases. Each chapter summarizes the prevalence and symptoms of the disease and explains the involvement of dopamine and/or glutamate systems using the newer molecular approaches such as transgenic knockout or knockin mice and recent brain imaging techniques.

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Product Details

Springer-Verlag New York, LLC
Publication date:
Edition description:
Product dimensions:
7.01(w) x 10.00(h) x 0.05(d)

Table of Contents

Part I. Dopamine

Dopamine Receptors

Kim A. Neve

Dopamine Receptor Alternative Splicing

Neil M. Richtand, Laurel M. Pritchard, and Lique M. Coolen

Part II. Glutamate

Glutamatergic Pathways: Their Relevance for Psychiatric Diseases

Yoland Smith

Glutamate Receptors: Ionotropic

Daniel T. Monaghan, Julia C. A. More, Bihua Feng, and David E. Jane

Metabotropic Glutamate Receptors

Krystyna Ossowska

Part III. Schizophrenia

Dopamine and Schizophrenia

Bart A. Ellenbroek

Glutamate and Schizophrenia and the N-Methyl-d-Aspartate Receptor Hypofunction Hypothesis

Stefan Bleich and Johannes Kornhuber

Role of Glycine in Schizophrenia

Beate D. Kretschmer

Part IV. Depression

Dopamine and Depression

Phil Skolnick

Glutamate and Depression

Joaquín Del Río and Diana Frechilla

Part V. Stress and Aggression

Dopamine, Glutamate, and Aggression

Klaus A. Miczek and Eric W. Fish

Part VI. Anxiety

Glutamatergic Systems and Anxiety

David N. Stephens

Part VII. Attention Deficit Hyperactivity Disorder

Dopamine and Glutamate in Attention Deficit Hyperactivity Disorder

James M. Swanson, Nora D. Volkow, Jeffrey Newcorn, B. J. Casey, Robert Moyzis, David K. Grandy, and Michael I. Posner

Part VIII. Addiction

Dopamine-Glutamate Interactions in Reward-Related Incentive Learning

Richard J. Beninger and Todor V. Gerdjikov

Sensitization and Relapse: Dopamine-Glutamate Interactions

David A. Baker and Peter W. Kalivas

Glutamatergic Neurotransmission in Sensitization

Thomas M. Tzschentke

Glutamatergic Mechanisms of Drug Relapse: Withdrawal and Conditioning Factors

Anton Y. Bespalov and Robert L. Balster

Part IX. Neurodegeneration

Dopamine and Neurodegeneration

Gabriele Gille and Peter Riederer

Glutamate and Neurodegeneration

Antonello Novelli, Marcos Pérez-Basterrechea, and Maria Teresa Fernández-Sánchez

Part X. Parkinson’s Disease

Presymptomatic and Symptomatic Stages of Intracerebral Inclusion Body Pathology in Idiopathic Parkinson’s Disease

Heiko Braak and Kelly Del Tredici

Dopamine and Glutamate in Parkinson’s Disease: Biochemistry, Clinical Aspects, and Treatment

Heinz Reichmann, Bernd Janetzky, and Peter Riederer

Dopamine and Glutamate in Motor and Cognitive Symptoms of Parkinson’s Disease

Werner J. Schmidt

Part XI. Huntington’s Disease

Dopamine and Glutamate in Huntington’s Disease

Carlos Cepeda, Marjorie A. Ariano, and Michael S. Levine

Part XII. Dementias

Dopaminergic and Glutamatergic Systems in Alzheimer’s Disease

Paul T. Francis


Product Details

ISBN-13: 9781588293251
Publisher: Springer-Verlag New York, LLC
Publication date: 03/18/2005
Edition description: 2005
Pages: 600
Product dimensions: 7.01(w) x 10.00(h) x 0.05(d)

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